Literature summary extracted from

Thillainayagam, M.; Malathi, K.; Anbarasu, A.; Singh, H.; Bahadur, R.; Ramaiah, S.
Insights on inhibition of Plasmodium falciparum plasmepsin I by novel epoxyazadiradione derivatives - Molecular docking and comparative molecular field analysis (2019), J. Biomol. Struct. Dyn., 37, 3168-3182 .

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
3.4.23.38	(1S,2aR,3aR,3bS,4R,9aR,11aS)-2-(((1-(2-cyanophenyl)-1H-1,2,3-triazol-4-yl)methoxy)imino)-1-(furan-3-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1,2,2a,3b,4,5,5a,6,7,9a,9b,10,11,11a-tetradecahydronaphtho(1,2':6,7)indeno(1,7a-b)oxiren-4-yl acetate	most active compound	Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number	Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
3.4.23.38	Hemoglobin + H2O	Plasmodium falciparum	-	?	-	?

Organism

EC Number	Organism	UniProt	Comment	Textmining
3.4.23.38	Plasmodium falciparum	P39898	-	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
3.4.23.38	Hemoglobin + H2O	-	Plasmodium falciparum	?	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
3.4.23.38	PM-I	-	Plasmodium falciparum

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
3.4.23.38	0.0017	-	pH and temperature not specified in the publication	Plasmodium falciparum	(1S,2aR,3aR,3bS,4R,9aR,11aS)-2-(((1-(2-cyanophenyl)-1H-1,2,3-triazol-4-yl)methoxy)imino)-1-(furan-3-yl)-3b,6,6,9a,11a-pentamethyl-7-oxo-1,2,2a,3b,4,5,5a,6,7,9a,9b,10,11,11a-tetradecahydronaphtho(1,2':6,7)indeno(1,7a-b)oxiren-4-yl acetate

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Release 2023.1 (January 2023)